Compliance-focused guides to the ISO 8655 gravimetric method, measurement uncertainty, calibration intervals, and NIST traceability — written for your regulatory framework, whether you run a pharmaceutical GMP operation or a CAP/CLIA clinical laboratory.
All calibrations are performed per ISO 8655 using the gravimetric method with NIST-traceable analytical balances. A partial list of manufacturers we service:
Level 2–4 services include calibration certificates with as-left volumetric accuracy data. Level 3–4 add as-found data for before/after documentation. Level 4 provides an ISO/IEC 17025 accredited certificate required for FDA, CAP, CLIA, cGMP, and GxP compliance submissions. For a detailed explanation of the ISO 8655 gravimetric method, systematic error, measurement uncertainty, and calibration intervals, see our pipette calibration guide for pharmaceutical & GMP laboratories.
No regulatory certificate required — the standard choice for general research and internal quality programs.
Femto Scientific provides calibrations, maintenance, and repairs on all types of pipettes including: Single Channel Pipettes, Multi Channel Pipettes, Electronic Single Channel Pipettes, Electronic Multi Channel Pipettes, Repeater Pipettes, Bottle Top Dispensers, Pipette Controllers, Positive Displacement Pipettes, and more!
| Service Includes | Level 1 | Level 2 | Level 3 | Level 4 |
|---|---|---|---|---|
| 15-Point Inspection | ✔ | ✔ | ✔ | ✔ |
| Internal and External Cleaning | ✔ | ✔ | ✔ | ✔ |
| Leakage and Function Testing | ✔ | ✔ | ✔ | ✔ |
| Full Range Calibration (ISO 8655 Gravimetric Method) | ✔ | ✔ | ✔ | ✔ |
| Preventative Maintenance (PM) | ✔ | ✔ | ✔ | ✔ |
| Calibration Sticker with Barcode | ✔ | ✔ | ✔ | ✔ |
| Calibration Certificate with As-Left Data | – | ✔ | ✔ | ✔ |
| Calibration Certificate with As-Found and As-Left Data | – | – | ✔ | ✔ |
| ISO/IEC 17025 Accredited Certificate with As-Found and As-Left Data | – | – | – | ✔ |
| Options | ||||
|
Express Turnaround
24 hr / 48 hr / 72 hr
|
✔ | ✔ | ✔ | ✔ |
| Onsite Service | ✔ | ✔ | ✔ | ✔ |
| Additional Volumes and Readings | ✔ | ✔ | ✔ | ✔ |
| Customized Services | ✔ | ✔ | ✔ | ✔ |
Level 3 and Level 4 calibration certificates satisfy CAP, CLIA, cGMP, and GxP documentation requirements for volumetric equipment.
Femto Scientific’s accredited calibration certificates and documentation packages meet the requirements of the most demanding regulatory frameworks in the life sciences.
Clinical laboratories accredited by the College of American Pathologists (CAP) or operating under CLIA require documented, traceable calibration of all volumetric equipment. Femto Scientific’s Level 3 and Level 4 calibration certificates satisfy these requirements with full as-found and as-left data and NIST-traceable measurement standards.
Pharmaceutical and biotechnology facilities operating under GxP or current Good Manufacturing Practice (cGMP) regulations require calibration records with unbroken NIST traceability and documented measurement uncertainty. Our ISO/IEC 17025 accredited certificates provide the complete documentation chain for FDA compliance and regulatory submissions.
Our calibration reports are structured to integrate with quality management systems (QMS) and laboratory information management systems (LIMS). Calibration certificates are available in electronic format with full measurement data for paperless quality workflows and instrument qualification programs.
ISO/IEC 17025 pipette calibration is performed by an accredited laboratory that has been independently assessed and found technically competent by a recognized accreditation body. The accreditation verifies that the laboratory’s reference instruments, measurement processes, and quality system are capable of producing metrologically valid calibration results with properly characterized measurement uncertainty. Femto Scientific’s ISO/IEC 17025 accredited calibration certificates carry NIST traceability and documented uncertainty, making them acceptable for CAP, CLIA, cGMP, FDA, and international quality auditors as evidence of instrument performance and regulatory compliance.
Calibration frequency depends on regulatory requirements, use intensity, and pipette criticality. cGMP pharmaceutical laboratories typically calibrate pipettes every 3–6 months; high-criticality instruments may require quarterly calibration. CAP and CLIA clinical laboratories require calibration at least annually, and most calibrate semi-annually. Research and academic laboratories without direct regulatory requirements calibrate annually at minimum. Femto Scientific can help you establish a calibration interval appropriate for your regulatory environment and document it in your instrument qualification program.
A NIST traceable calibration certificate documents that your pipette’s accuracy was tested using measurement standards with an unbroken chain of comparisons to the National Institute of Standards and Technology national measurement standards. For pipette calibration, traceability runs through the analytical balance (mass traceability) and thermometer (temperature traceability) used in the gravimetric calibration. Femto Scientific’s reference instruments are maintained on a documented recertification schedule, and each certificate identifies the reference instruments and their traceability — satisfying FDA, CAP, CLIA, and ISO documentation requirements.
Yes. Femto Scientific provides onsite pipette calibration and repair across major U.S. laboratory markets including New York, New Jersey, Boston, Philadelphia, Baltimore, Connecticut, California, Texas, and more. Onsite service is available at all four service levels and is ideal for laboratories that cannot ship instruments or require zero instrument downtime. Laboratories outside our direct service territory can use our secure, fast-turnaround mail-in pipette calibration service with NIST traceable certificates delivered electronically before instruments ship back.
We calibrate and repair pipettes from all major manufacturers including Gilson (PIPETMAN Classic, Neo, Connect, M, L), Eppendorf (Research plus, Xplorer, Multipette, Repeater M4), Rainin (PIPET-X, Classic, Liquidator 96), Sartorius (Picus, Tacta, Biohit mLINE), Thermo Fisher Scientific (Finnpipette, F1-ClipTip), BrandTech, Drummond, Biohit, VWR, Matrix, Hamilton, and Vistalab/MLA. If your brand or model is not listed, contact us — our technicians service virtually all makes and models of piston-operated and electronic pipettes.
Femto Scientific provides onsite pipette calibration and repair in major laboratory markets across the United States. Laboratories outside our onsite territory can take advantage of our secure, fast-turnaround mail-in pipette calibration service with NIST traceable certificates delivered electronically.
Mail-in pipette calibration service is available to any laboratory in the United States. Contact us for shipping instructions and a service quote.